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KMID : 1098420040120020108
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Korean Journal of Medicinal Crop Science
2004 Volume.12 No. 2 p.108 ~ p.112
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Effects of Medicinal Plant Extracts on Antioxidant System in Ethanol-intoxicated Rats
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Lee Seung-Eun
Bang Jin-Ki
Seong Nak-Sul
Kim Ji-Eun
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Abstract
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Four medicinal plants selected from preliminary screening study were evaluated in the aspects of their antioxidant activities in alcohol-intoxicated rats. Rats fed 1% {alpha}-tocopherol-supplemented diet as positive control and ones done {alpha}-tocopherol-deficient diet as negative control were compared with ones done the plant extract-supplemented diet (n=8). After the administration of the experimental diets for 4 weeks, typical increments in activities of manganese-superoxide dismutase (Mn-SOD) and glutathione peroxidase (GSH-px) indicated in alcohol-intoxicated rats, were not observed in ones fed Lagerstroemia and Ulmus extract-supplemented diet. The content of thiobarbituric acid reactive substance (TBARS), the product of lipid peroxidation, did not increased in rats fed plant extracts-supplemented diet except for Terminalia. From the results, it is concluded that Lagerstroemia and Ulmus have physiologically efficient antioxidant activities.
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KEYWORD
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medicinal plants, peroxidation, antioxidant, alcohol, superoxide dismutase, glutathione peroxidase, catalase
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